Calcium Levofolinate - GMT Fine Chemicals SA - The Folate specialist

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Calcium Levofolinate

Calcium Levofolinate (Levoleucovorin Calcium)
CAS registry number : [80433-71-2]

Calcium Levofolinate is the natural, biologically active, diastereoisomer of the Calcium Folinate.
The carbon at position 6 is an asymetric centre and the product only contains the pure (6S)-isomer.
Calcium Levofolinate
The Calcium Levofolinate Pentahydrate active substance manufactured by GMT Fine Chemicals SA is a powder having a stable crystalline form and is in full compliance with the monograph of the European Pharmacopoeia.

The Calcium Levofolinate Pentahydrate is packed
into PE/PA/PE bag under vacuum and sealed, then put into aluminium bag under vacuum and sealed.

Calcium Levofolinate is used primarily for the production of injectable galenical forms in treatment of certain cancers as an antidote to folic acid antagonists, such as methotrexate, which block the conversion of folic acid to folinic acid or in association with 5-fluorouracil.
As the biologically active isomer, Calcium Levofolinate is administered to patients at half the dose of the Calcium (RS)-Folinate.

GMT Fine Chemicals SA
is the holder of the Certificate of Suitability for Calcium Levofolinate Pentahydrate, granted by the European Directorate for the Quality of Medicines (EDQM) and a US-DMF
available for Reference as Type II DMF.

For more information or to place an order please use our Inquiry Form.
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