Calcium Levofolinate is the natural, biologically active, diastereoisomer of the Calcium Folinate. The carbon at position 6 is an asymetric centre and the product only contains the pure (6S)-isomer.
The Calcium Levofolinate Pentahydrate active substance manufactured by GMT Fine Chemicals SA is a powder having a stable crystalline form and is in full compliance with the monograph of the European Pharmacopoeia.
Packaging The Calcium Levofolinate Pentahydrate is packed into PE/PA/PE bag under vacuum and sealed, then put into aluminium bag under vacuum and sealed.
Use Calcium Levofolinate is used primarily for the production of injectable galenical forms in treatment of certain cancers as an antidote to folic acid antagonists, such as methotrexate, which block the conversion of folic acid to folinic acid or in association with 5-fluorouracil. As the biologically active isomer, Calcium Levofolinate is administered to patients at half the dose of the Calcium (RS)-Folinate. GMT Fine Chemicals SA is the holder of the Certificate of Suitability for Calcium Levofolinate Pentahydrate, granted by the European Directorate for the Quality of Medicines (EDQM) and a US-DMF available for Reference as Type II DMF.
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