Calcium Folinate (Leucovorin Calcium)
CAS registry number: [1492-18-8]
The carbon at position 6 is a chiral center and the product is a mixture of a 1 : 1 ratio of the (6R)- and (6S)-isomers.
The Calcium Folinate active substance manufactured by GMT Fine Chemicals SA is a powder having a stable crystalline form.
The Calcium Folinate is packed in double, low-density polyethylene bags, placed in high-density polyethylene containers.
Calcium Folinate is used for the production of oral and injectable galenical forms. It is administered primarily as an antidote to folic acid antagonists, such as methotrexate, which blocks the conversion of folic acid to folinic acid.
GMT Fine Chemicals SA is the holder of the Certificate of Suitability for Calcium Folinate EP, granted by the European Directorate for the Quality of Medicines (EDQM).
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